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“However, 62.5 mg and 125 mg of caffeine administered simultaneously with 10 mg of morphine or 60 mg of codeine intramuscularly produced significant antagonism of the respiratory depression.”
The Journal of pharmacology and experimental therapeutics • 1962 | View Paper
“Other drugs oxidized by microsomes such as caffeine , phenobarbitone and hexobarbitone had either no or little effect on lipid peroxide formation, but codeine inhibited.”