Possible Interaction: Caffeine and Cocaine

“ Caffeine also dose-dependently increased the frequency of stimulant identifications on the Pharmacological Class Identification Questionnaire (e.g., like cocaine , amphetamine).”

“ Caffeine also produced negative-mood effects (e.g., increased ratings of bad effects) and increases in self-reported desire for cocaine.”

“Adolescent consumption of caffeine also enhanced the development of a conditioned place preference at a sub-threshold dose of cocaine (7.5 mg/kg, i.p.).”

“ Caffeine consumption during adolescence reduced basal dopamine levels and augmented dopamine release in the NAc in response to cocaine (5 mg/kg, i.p.).”

“There is evidence for caffeine withdrawal symptoms, and caffeine does act as a weak reinforcer, but neither effect is as pronounced as those associated with cocaine.”

“Caffeine had no significant effect on subject-rated and physiological response to cocaine, with the exception that caffeine significantly augmented blood pressure response to cocaine.”

“Interestingly, regular caffeine use was associated with less frequent cocaine use within the cocaine-dependent sample.”

“Objectives Our aim was to study ion conductances that have important implications regulating sleep–wake states 24-h after an acute or chronic binge-like administration of a cocaine and caffeine mixture following previously analyzed pasta base samples (“PACO”-like binge”) using mice.”

“Results Our results showed notorious changes in the intrinsic properties of the VB nucleus neurons that persist after 24-h of either acute or chronic binge administrations of combined cocaine and caffeine (“PACO”-like binge).”

“Our data indicate that caffeine produces a significant potentiation of the wakefulness-promoting effect of cocaine , suggesting that caffeine should be explored as a causal agent of clinical symptoms observed in CP users.”

“Animal studies have demonstrated that caffeine is able to potentiate several cocaine actions , although the enhancement of the cocaine reinforcing property by caffeine is less reported, and the results depend on the paradigms and experimental protocols used.”

“Interestingly, the breaking point determined for the cocaine + caffeine group was significantly higher than the cocaine group.”

“ObjectivesWe examined the ability of caffeine to enhance the motivational and rewarding properties of cocaine using an intravenous self-administration paradigm in rats.”

“We found that chronic caffeine potentiated locomotion induced by cocaine and that both caffeine-treated groups showed sensitization.”

“Caffeine is likely added to these preparations because it is inexpensive and legal; however, caffeine might also mimic or enhance some of the effects of cocaine or MDPV.”