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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In … patients caffeine-containing coffee increased the mean … concentration of clozapine by 26% (non-significant (NS), 95% CI -3% to +54%, P=0.07), N-desmethylclozapine by 6% (95% CI … 12%, P=0.03), and clozapine-N-oxide by 7% (NS, 95% CI -6% to +20%, P=0.22).”
“Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations.”
“The increase in serum clozapine concentration was most likely due to the inhibition of the CYP1A2 enzyme by caffeine.”
Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients.“Moreover, individual caffeine and clozapine clearances were found to be significantly related (R: 0.62; P<0.05) as were clozapine dose per kg body weight and P/C mol ratio (R: 0.44; P<0.05).”
“CONCLUSIONS These results suggest that ca feine in daily doses of 400-1000 mg inhibits the metabolism of clo zapine to an extent that might be clinically significant in certain individuals.”
“On the other hand, caffeine might increase the level of clozapine , and more research in this area is needed.”
“We present a case of severe toxicity associated with the co-consumption of caffeine and Clozapine culminating in life-threatening complications requiring management in Intensive Care.”
“Smoking and excessive caffeine use are associated with poor therapeutic responses to clozapine and should be considered in the pharmacological management of treatment-refractory psychosis, regardless of the primary diagnosis.”
“However, dose reduction in concomitant caffeine , benzodiazepines and neuroleptic drugs (especially clozapine ) may be warranted, because polyaromatic hydrocarbons present in smoke induce CYP 1A2.”
“There are numerous clinically significant interactions between clozapine and other substances, including prescribed medications, nicotine and caffeine.”
“We believe the combination of clozapine and caffeine at the time of ECT was responsible for the arrhythmia.”
“ Caffeine can inhibit the metabolism of some psychotropic drugs such as clozapine through the competitive inhibition of CYP 1A2 .”
Caffeine: The forgotten variable
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