Possible Interaction: Caffeine and Clomipramine

“Fetuses of rats receiving high doses of caffeine or combinations of caffeine and clomipramine showed a significant rate of cleft palate development, open eyelids, mortality, torsion anomalies, shrinkage of skin, and subcutaneous haemorrhage (P ≤ 0.001).”

“This study concludes that caffeine in high doses or the simultaneous administration of caffeine and clomipramine leads to teratogenicity.”

“Moreover, CLM significantly increased the duration of climbing but only CAF increased the frequency of climbing.”

“Therefore, it can be concluded that the serotonin system interacts with the analgesic action of caffeine and that a long-term use of clomipramine probably triggers subsensitivity of adenosine receptors.”

“ Clomipramine showed distinct inibition of 1-N- and 3-N-demethylation and 8-hydroxylation of caffeine , the effects on N-demethylations being the most pronounced (Ki = 38.6, 34.8, 45.6 microM, respectively).”

“ Chlorimipramine‐ and desimipramine‐elicited depressions were antagonized by intravenously administered caffeine , an adenosine antagonist.”