Possible Interaction: Caffeine and Cisplatin

“Results: Tumors regressed after treatment with CDDP plus o-rMETase with caffeine.”

“Tumors treated with CDDP plus o-rMETase with caffeine also had the most necrosis.”

“The combination of CDDP and caffeine more markedly prolonged the survival time than CDDP alone or caffeine alone.”

“This study was conducted to clarify the enhancement of the anti-tumor effect of CDDP by caffeine using a tumor-bearing peritoneal disseminated metastasis model in vivo.”

“A nontoxic dose of caffeine enhanced the cytotoxicity of cisplatin in human osteosarcoma cells (OST strain).”

“ Caffeine reduced S-phase, G2/M-phase, and S-and-G2/M-phase accumulation by cisplatin on the DNA histogram, and nuclear fragmentation of tumor cells was frequently observed.”

“Synergistic cytotoxicity was seen in vitro in OST cells when 2 mmol caffeine was added to a nontoxic dose of cisplatin (2 micrograms/ml).”

“These results indicate that caffeine enhances the antitumor effect of cisplatin on transplanted osteosarcoma in BALB/C athymic mice.”

“When 4 mg of caffeine was given once a day for three days after the administration of cisplatin , marked regression of the tumor was observed in groups treated with 5 or 10 mg/kg of cisplatin, without significant weight loss.”

“We demonstrated previously that the effect of cis-diamminedichloroplatinum(II) (cisplatin) against pancreatic cancer was substantially enhanced by the addition to the chemotherapeutic regimen of 1-beta-D-arabinofuranosylcytosine and caffeine.”

“The combination of cisplatin and caffeine together reduced the survival rate for MDA-MD231 and shifted their energy metabolism to a higher fraction of bound NADH indicative of oxidative phosphorylation.”

“ Caffeine (200 µg/mL) promoted apoptosis and inhibited the increase in the proportion of viable cells in S phase that occurred in the presence of 3.8 µg/mL cisplatin.”

“ Caffeine (≥100 µg/mL) significantly enhanced the antiproliferative activity induced by 3.8 µg/mL cisplatin.”

“ Caffeine increases the anticancer activity of cisplatin by inhibiting DNA repair; however, details of the mechanism remain unclear.”

“In conclusion, caffeine enhances the anticancer effect of cisplatin by inhibiting FANCD2 monoubiquitination.”

“We investigated the mechanism responsible for the synergistic anticancer effect of cisplatin and caffeine in HepG2 human hepatocellular carcinoma cells, focusing on the FA pathway.”

“ Caffeine overcame the cell‐cycle arrest induced by cisplatinum , thereby increasing its efficacy, since cisplatinum is ineffective against quiescent cells.”

“Clonogenic assays showed that caffeine increased the inhibition by cisplatinum on cell proliferation.”

“The combination of cisplatinum and caffeine enhanced mitosis and subsequently increased apoptosis.”

“The data in this report indicate that caffeine modulates the cell cycle in cancer cells, thereby enhancing efficacy of cell‐cycle‐dependent anticancer drugs such as cisplatinum.”

“As a result, caffeine increased the antitumor effect of cisplatin on cell proliferation and cell apoptosis in the HCC cell lines.”

“ Caffeine is thought to increase the antitumor effect of cisplatin or DNA-damaging agents because it is known that caffeine inhibits DNA repair.”

“ Caffeine enhances the effect of cisplatin (CDDP) chemotherapy on osteosarcoma cells.”

“Myc-AS or caffeine can enhance the cytotoxic effects of 2.0 and 5.0 μg/ml CDDP on MG-63 cells.”

“Sarcospheres showed strong resistance to doxorubicin and cisplatin , and caffeine , a DNA repair inhibitor, enhanced the efficacy of those drugs, suggesting that the drug resistance in sarcosphere cells was partly related to the efficient DNA repair ability.”