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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Chlorpromazine
Research Papers that Mention the Interaction
“Furthermore, chlorpromazine and caffeine were shown to act synergistically to potentiate the cytogenetic effect of adriamycin on human lymphocytes in vitro and on Ehrlich ascites tumour (EAT) cells in vivo.”
Chlorpromazine-induced damage on nucleic acids: a combined cytogenetic and biochemical study.“ CPZ induces cytotoxic effects in combination with caffeine (CAF) and alkylating agents.”
“In combination with chlorambucil (CBC) and CAF, CPZ produced synergism on induction of SCEs, enhanced cell division delays and reduced MIs.”
“Thioridazine was a weaker inhibitor of caffeine 3-N- and 7-N-demethylation, while chlorpromazine was weaker in inhibiting caffeine 1-N- and 7-N-demethylation, compared to levomepromazine.”
Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver.“GSH and caffeine increased and chlorpromazine decreased the radiation-induced activity of GI, but all three modifiers enhanced radiation-induced inactivation of GII.”
“Increases in response rates produced by caffeine were altered by chlorpromazine similarly to the manner in which (-)-PIA altered effects of caffeine.”
“3 The contraction evoked by excess [K]o, NaCl‐free Krebs and by caffeine was suppressed by application of chlorpromazine ; contractions induced by the former two treatments were suppressed to a greater extent than those induced by the latter.”
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