Possible Interaction: Caffeine and Chlorogenic Acid

“High performance liquid chromatography (HPLC) analysis showed that the content of caffeine (41.58 ± 0.54 μg/mg) was higher than that of chlorogenic acid isomers (~9.17 μg/mg) in ESCG.”

“… chlorogenic acid may have antihypertensive effects.• There is a significant … decrease following green coffee consumption (215–280 mg caffeine ), and these changes are observed in individuals whose usual dietary caffeine intake is relatively both … intake was in the 50th percentile or greater (relatively high) increased after green coffee consumption.”

“Moreover, CGA + caffeine inhibited the mRNA expression of major adipogenic markers, PPAR-γ2, and C/EBPα in the metaphase and anaphase stages of differentiation induction (Day 2 and 4).”

“The combination of CGA and caffeine effectively decreased body weight gain, intraperitoneal adipose tissue weight, serum LDL-c, FFA, TC, TG, leptin, IL-6 concentrations, and hepatic TG and TC levels and increased the serum adiponectin level.”

“The results indicated that the combination of CGA and caffeine had anti-obesity effects and regulated lipid metabolism in high-fat diet-induced obese mice via the AMPKα-LXRα/SREBP-1c signaling pathway.”

“The CGA and caffeine combination also promoted the phosphorylation of AMPKα, inhibited the expressions of transcriptional regulators (SREBP-1c and LXRα), and decreased the expressions of FAS and HMGR.”

“The evidence reported in the study suggested the hypothesis that CGA and caffeine exert their action by biological synergism and that, more generally, coffee polyphenols usually work through a synergistic mechanism.”

“Addition … chlorogenic acid , a molecule found in coffee and other plants and … to modify, by complexation, the physiological effects of caffeine , had no significant effect on the depressor responses to caffeine but did diminish caffeine-induced tachycardia at high doses of caffeine (10 and 30 mg/kg i.v.).”

“The 3D fluorescence, UV/vis and FTIR spectra also showed that the binding of CF with CFA and CGA induces conformational changes in CFA and CGA.”

“The range error ratio (RER) was higher for caffeine (17.8) when compared to other compounds (12.0, 10.1, 7.6 and 9.2, respectively for caffeic acid, (+)-catechin, chlorogenic acid and theophylline).”

“Complex formation of caffeine with chlorogenic acid is also discussed as this may also help explain caffeine’s localization.”

“ Decaffeination produced a 16% average increase in the levels of total CGA in green coffee (dry matter), along with a 237% increase in CGL direct precursors.”