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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Ceftriaxone
Research Papers that Mention the Interaction
“ Caffeine increased the volume of distribution of the central compartment (V1) for ceftriaxone significantly from 49 ± 38 ml kg−1 (mean ± s.d.,”
“Rabbit plasma concentrations of ceftriaxone (30 mg kg−1 i. v.) were elevated significantly (P <005 at 0.3, 0.6 and 1 h after injection) when caffeine 5 or 10 mg kg−1 i.v.”
“The rate of transfer of ceftriaxone to the peripheral compartment (k12) was also decreased significantly (P <0.05) after caffeine.”
Effect of caffeine on the plasma protein binding and the disposition of ceftriaxone“These results suggest that caffeine does not alter the protein binding of ceftriaxone, but enhances the elimination of ceftriaxone in the rat.”
Effect of caffeine on ceftriaxone disposition and plasma protein binding in the rat
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