Possible Interaction: Caffeine and Catechin

“Taken together, our data indicated that caffeine and theanine, glycine, or serine in tea might increase the absorption of catechins by the selectively suppressed expression of the efflux transporters induced by catechins.”

“The results suggest that habitual caffeine intake and ethnicity may be moderators, as they may influence the effect of catechins.”

“Intracellular lipid accumulation and glycerol-3-phosphate dehydrogenase activity were strongly suppressed by catechins and caffeine combination treatment.”

“PRACTICAL APPLICATION: In this study, we revealed that the combined treatment of catechins and caffeine inhibited lipid synthesis and improved lipid metabolism in adipocytes.”

“Our research clearly demonstrated that the combined treatment of catechins and caffeine showed the inhibitory effect on the development of atherosclerosis in mice.”

“These results indicated that the combined administration of catechins and caffeine has the inhibitory effect on the development of atherosclerosis in mice.”

“This study indicates that chronic intake of both caffeine and catechins can synergistically contribute to prevention of obesity and lifestyle-related diseases.”

“… caffeine … catechins significantly upregulated mRNA and protein expression levels of lipases while downregulating FAS mRNA expression and protein expression of peroxisome proliferator-activated receptor γ2.ConclusionsThe … metabolism-related enzymes, resulting in suppression of body weight gain and IPAT weight in mice, potentially through activation of the AMPK signaling pathway.”

“Moreover, it was shown that catechins and caffeine were synergistic in anti-obesity activities.”

“ Caffeine weakly inhibited the response in a competitive manner (K(i) = 15 mM), and (+)-catechin inhibited it in a noncompetitive one (K(i) = 1.7 mM).”

“ Caffeine , administered together with thymosine, inhibited the protein synthesis by 80% in C and D thymocyte subpopulations and - by 47% in B subpopulations.”

“The stimulatory effects of poly A:U and poly I C on antibody formation can be potentiated by the concurrent administration of theophylline or caffeine.”

“However, low concentrations of catechin synergistically potentiated the mast cell-stabilizing property of caffeine.”

“However, surprisingly enough, low concentrations of catechin (1, 2.5 mM) synergistically enhanced the suppressive effect of 10 mM caffeine on mast cell degranulation.”

“These results provided direct evidence for the first time that caffeine and catechin dose-dependently inhibited the process of exocytosis.”