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Possible Interaction: Caffeine and Carbachol

supplement:

Caffeine

Research Papers that Mention the Interaction

Caffeine did not block the Ca(2+) entry, but significantly inhibited carbamylcholine (CCh)-induced Ca(2+) release.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology  •  2010  |  View Paper
Whereas 20mM caffeine had no effect on basal [Ca(2+)](i) or the slow rise in response to CPA, it completely prevented the CPA-induced [Ca(2+)](i) transients as well as inositol 1,4,5-trisphosphate-mediated [Ca(2+)](i) transients in response to carbachol.
Cell calcium  •  2004  |  View Paper
Caffeine (a nonselective antagonist of adenosine receptors) potentiates the action of carbamylcholine during the first hour and then ceases to influence the drug effect.
Eksperimental'naia i klinicheskaia farmakologiia  •  2009  |  View Paper
In bladders, caffeine (30 mM) but not ryanodine (5 microM) prevented the subsequent carbachol contraction.
European journal of pharmacology  •  2007  |  View Paper
Identical patterns of Ca(2+) depletion were seen when caffeine (1 microM) and carbachol (10 microM) were applied sequentially to the same cells, suggesting that activation of ryanodine and IP(3)-sensitive channels can result in the release of Ca(2+) from the same regions of the SR.
Cell calcium  •  2002  |  View Paper
The effect of carbachol in 0 Ca2+ solution was reduced by using drugs that reduce intracellular pools of Ca2+, such as caffeine (1–3 mM), ryanodine (30 µM) or thapsigargin (1 µM), corroborating the involvement of intracellular Ca2+ stores.
Pflügers Archiv  •  2001  |  View Paper
The relaxation with caffeine was significantly accelerated in those strips precontracted with KCl or CCh.
British journal of pharmacology  •  2001  |  View Paper
Pretreatment with carbachol suppressed ICAF to 22 +/- 7% (n = 7) and the caffeine-induced [Ca2+]i elevation to 25 + 3% (n = 6).
European journal of pharmacology  •  1998  |  View Paper
10 mM caffeine (CAF) increased of [Ca2+]i in NPE and PE (NPE > PE) and sometimes produced very slow oscillations with an interval of 10 to 25 s. Prior administration of CAF strongly suppressed the effects of ACH, CARB , EPI, PHE, histamine, and adenosine 5-triphosphate (ATP).
Current eye research  •  1997  |  View Paper
Caffeine (10 mM) activated both ICl(Ca) and I(DOC) and prevented the induction of I(oscil) by carbachol.
Caffeine and CPA also abolished I(oscil) in the presence of carbachol , as did both a low (3 microM) and a high (30 microM) concentration of ryanodine.
British journal of pharmacology  •  1997  |  View Paper
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