Use of oral contraceptives blunts the calciuric effect of caffeine in young adult women.

 consumption increases the urinary excretion of 

Caffeine inhibits InsP3 responses and capacitative calcium entry in canine pulmonary arterial smooth muscle cells.

These studies provide the first evidence that

Toxoplasma gondii Microneme Secretion Involves Intracellular Ca2+ Release from Inositol 1,4,5-Triphosphate (IP3)/Ryanodine-sensitive Stores*

We identified two stimuli of microneme secretion, ryanodine and

Caffeine, urinary calcium, calcium metabolism and bone.

, magnesium, sodium and chloride for at least 3 h after consumption.

Dietary factors influencing calcium and bone metabolism: introduction.

Concerns have arisen that overly generous consumption of sodium,

 and phosphate may be detrimental to bone, as may be low dietary intakes of potassium, especially when 

Effect of caffeine on tone and intracellular Ca++ release in guinea-pig and human trachealis.

 appears to surpass the antispasmodic effects of beta-adrenergic stimulation, at least in part, by depleting intracellular stores of 

Effects of milrinone on Ca++-sensitivity of myofibrillar Mg-adenosine triphosphatase isolated from normal human and canine hearts.

, at concentrations of 40 mM, caused statistically significant sensitization of canine and human myofibrils to 

Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants

 (within 2 days of birth) had lower odds of sNDI at 18 to 24 months’ 

Coffee and tea: perks for health and longevity?

 at high doses can increase anxiety, insomnia, 

[Coffee and caffeine - enemies or alliantes of a cardiologist?].

 accumulation in the mitochondria of cardiomyocytes.

Non-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club

The effect of other nutriments is less clear, although an excessive consumption of sodium,

Caffeine and the calcium economy revisited

 suggests that it can be offset by increasing calcium intake by about 1 mmol (40 mg) for every 177.5 ml serving of caffeine-containing coffee.

We found a caffeine relationship such that for every 6 fl oz (177.5 ml) serving of

 was more negative by 0.114 mmol/day (4.6 mg/day) (P<0.001).

Is caffeine a risk factor for bone loss in the elderly?

 on bone loss was reported by Harris and Dawson-Hughes (7).

Mechanisms through which PDGF alters intracellular calcium levels in U-1242 MG human glioma cells

To study the participation of intracellular calcium stores in this process, we used thapsigargin,

 and ryanodine, all of which cause depletion of intracellular 

The modulation and characterisation of the Ca2+‐induced Ca2+ release mechanism in cultured human myometrial smooth muscle cells

Caffeine did not activate 45Ca2+ release although ryanodine induced 45Ca2+ release and

Calcium ionophore increases amyloid beta peptide production by cultured cells.

 also increased A beta production, possibly through release of 

The actions of caffeine and 2,3‐butanedione monoxime on calcium transients in human vascular smooth muscle

 inhibited both the depolarization‐ and histamine‐induced increases in intracellular 

Caffeine and the risk of hip fracture: the Framingham Study.

 output and has been implicated as a risk factor for osteoporosis.

Effects of dietary caffeine on renal handling of minerals in adult women.

 (98.6% to 97.5%, p less than .001) and magnesium (97.0% to 94.2%, p less than .0001) decreased significantly during the 

Caffeine sensitivity of sarcoplasmic reticulum of fast and slow fibers from normal and malignant hyperthermia human muscle

Human slow‐fiber SR is more sensitive to caffeine than fast fiber SR; however, it releases less

 and at a lower rate than the SR of fast fibers when exposed to threshold concentrations of 

Effect of anti-Ig on cytosolic Ca2+ in Daudi lymphoblastoid cells.

 (4 mM) and 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate HCl (0.5 mM) suppressed the release of 

 from internal stores and the entry of calcium from outside the cells, but permitted capping in more than half of the cells.

Paradoxical stimulation of human sperm motility by 2-deoxyadenosine.

 and 2-deoxyadenosine to influence sperm … was counteracted by the presence of 

 in the external medium although the latter was less susceptible to such inhibition and still enhanced motility … the presence of calcium levels (1.7 mM) typical of media used for in-vitro fertilization.

Caffeine and Endurance Performance

 has been implicated to affect the translocation of 

 in muscle, promote an increase in cellular levels of cyclic AMP and cause a blockade of adenosine receptors in the central nervous system.

Electromechanical effects of caffeine in isolated human atrial fibres.

 influx and enhances the release of Ca from the intracellular stores in human atrial fibres.

Effects of nitrogen, phosphorus, and caffeine on calcium balance in women.

 was associated with higher levels of both 

Activation of Cav1.2 and BKCa is involved in the downregulation of caffeine-induced contraction in mice mesenteric arteries.

-influx via TRPs and Cav1.2, and hyperpolarization through the activation of BKCa, inducing negative feedback of TC.

Calcium stores regulate excitability in cultured rat hippocampal neurons.

, and calcium store antagonists cyclopiazonic acid or thapsigargin blocked this action.

Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions

 resulted in a brief increase in the amplitude of the systolic 

 transient accompanied by an increase of action potential duration.

The effect of caffeine on hearing in a guinea pig model of acoustic trauma.

 is a widely consumed substance affecting the metabolism of adenosine and cellular metabolism of 

Consumption of an acute dose of caffeine reduces acquisition but not memory in the honey bee

 affects several molecules that are also involved in the processes underlying learning and memory such as cAMP and 

Role of Stored Calcium in the Regulation of Neurotransmitter Quantum Size

 during activation of ryanodine receptors with ryanodine or 

 elevates the mean amplitude of spontaneous miniature end-plate potentials.

Bone quality associated with daily intake of coffee: a biochemical, radiographic and histometric study.

 and influences the normal development of bone.

Caffeine induces ram sperm hyperactivation independent of cAMP-dependent protein kinase.

 induced a significant increase in the content of 

 in viable spermatozoa during the time-course of incubation in capacitating conditions.

Caffeine – a valuable tool in excitation–contraction coupling research

 causes an increase in the open probability of the SR Ca2+-release channel (Rousseau et al. 1988) and renders it more sensitive to voltage sensor activation and physiological activators such as 

 and ATP (Shirokova & Rios, 1996; Herrmann-Frank et al. 1999).

Calcium Induces Increases in Peroxisome Proliferator-activated Receptor γ Coactivator-1α and Mitochondrial Biogenesis by a Pathway Leading to p38 Mitogen-activated Protein Kinase Activation*

We found that treatment of rat epitrochlearis muscles with a concentration of

 to a concentration too low to cause contraction induces increases in peroxisome proliferator-activated receptor γ coactivator-1α expression and mitochondrial biogenesis.

[Ca2+-signaling in smooth muscles cells of the airways in T-bet knock-out mice].

Emptying intracellular Ca (2+)-stores using

 (2+)-elevations in ASMC from T-bet KO compared to wild-type mice.

Depressing Effects of Caffeine at Crayfish Neuromuscular Synapses I. Dosage Response and Ca++ Gradient Effects

 concentrations delayed or depressed the 

 depending on the calcium gradient across the membrane or the caffeine dosage.

Involvement of calcium mobilization from caffeine-sensitive stores in mechanically induced cell cycle arrest in the dinoflagellate Crypthecodinium cohnii.

 also inhibited the ability of the other agent in mobilizing CTC-positive 

Mitochondrial modulation of Ca2+ -induced Ca2+ -release in rat sensory neurons.

A subset of rat dorsal root ganglion neurons in culture exhibited regenerative

 concentration decreased the threshold for action potential-evoked 

Caffeine inhibition of calcium accumulation by the sarcoplasmic reticulum in mammalian skinned fibers

Calcium handling by the sarcoplasmic reticulum during oscillatory contractions of skinned skeletal muscle fibres

 sensitivity of the contractile apparatus and, at low calcium concentrations, SR Ca uptake.

Control of pulmonary vascular smooth muscle tone by sarcoplasmic reticulum ca2+ pump blockers: thapsigargin and cyclopiazonic acid

In chemically (β-escin)-skinned arterial strips, application of TG (0.1–… (0.5–10 μM) prior and throughout the loading procedure of the

 stores (0.3 μM free Ca2+ ions for 8–10 min) … the subsequent contractile response induced by noradrenaline (NA, 10 μM) or 

Frequency‐dependent requirement for calcium store‐operated mechanisms in induction of homosynaptic long‐term depression at hippocampus CA1 synapses

It is therefore suggested that calcium release from

 contributed to the LTD enhancement, and that the caffeine effect was exerted on the postsynaptic side.

Myofibrillar responsiveness to cAMP, PKA, and caffeine in an animal model of heart failure.

, however, resulted in a greater leftward shift on the 

Caffeine enhances the calcium-dependent cardiac mitochondrial permeability transition: relevance for caffeine toxicity.

 not only hindered mitochondrial capacity to recover membrane potential after 

 addition but also increased the rate of calcium-dependent mitochondrial swelling and calcium-induced calcium release.

 reduced mitochondrial ability to accumulate 

 by increasing the susceptibility of heart mitochondria to the opening of the transition pore.

Control of Calcium Homeostasis by Angiotensin II in Adrenal Glomerulosa Cells through Activation of p38 MAPK*

 reduced both the angiotensin II-induced 

 and aldosterone production in bovine glomerulosa cells.

Effects of caffeine and exercise on the development of bone: a densitometric and histomorphometric study in young Wistar rats.

 and influence the normal development of bone, whereas the proper exercise has positive effects on bone metabolism.

Repetitive application of caffeine sensitizes caffeine-induced Ca2+ release in bullfrog sympathetic ganglion neurons

The repetitive or sustained application of

 is suggested to increase the caffeine sensitivity of the calcium release channel to 

, thus causing the potentiation of the caffeine response.

The Effects of HCl and CaCl2 Injections on Intracellular Calcium and pH in Voltage-clamped Snail (Helix aspersa) Neurons

These results suggest that low pHi has little effect on the plasma membrane calcium pump (PMCA) but important effects on the

Increased Store-Operated Ca2+ Entry into Contractile Vascular Smooth Muscle following Organ Culture

Following depletion of intracellular Ca2+ stores by

 (2.5 mM) caused an increase in the intracellular Ca2+ concentration which was 2–3 times greater in cultured than in freshly dissected rings, and was not affected by verapamil (10 µM).

Oxygen-induced fetal pulmonary vasodilation is mediated by intracellular calcium activation of K(Ca) channels.

 (0.5 mM) and diltiazem also decreased intracellular 

Physiology and excitation-contraction coupling in the intestinal muscle of the crayfish Procambarus clarkii

 application causes an increase in tonus and size of phasic contractions by circumventing the sarcolemma and dumping SR 

The effects of intracellular pH changes on resting cytosolic calcium in voltage‐clamped snail neurones

 rise induced by TMA (3 mM) was reduced by 60 ± 5% following a 10 min period of superfusion with 

 (10 mM) to deplete the endoplasmic reticulum (ER) stores of calcium (P < 0.05).

 increase was much reduced following application of 

, treatment with CPA or prolonged removal of external calcium.

The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes.

[Effect of caffeine on tension development of skeletal muscle of mdx mouse].

[Effects of olprynone hydrochloride and milrinone on the Ca(2+)-related functions of skinned skeletal muscle fibers from the guinea pigs].

It was reported that phosphodiesterase (PDE) inhibitors such as

, theophylline and amrinone accelerate Ca(2+)-induced 

 (CICR) rate from sarcoplasmic reticulum (SR) in skeletal muscle.

A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes

 (10 mM) resulted in a Na-Ca exchange current and a transient increase of the free intracellular 

Adenine-nucleotide binding sites on the inositol 1,4,5-trisphosphate receptor bind caffeine, but not adenophostin A or cyclic ADP-ribose.

Since the adenine-containing compounds adenophostin A,

 and cyclic ADP-ribose modulate IP3-induced 

 release, a possible effect of these compounds on the ATP-binding sites was examined.

Superficial buffer barrier and preferentially directed release of Ca2+ in canine airway smooth muscle.

 (5 mM), ryanodine (0.1-30 microM), and 4-chloro-3-ethylphenol (0.1-0.3 mM), all of which trigger 

-induced Ca2+ release, evoked Ca2+ transients and membrane currents but not contractions.

Ca2+ images and K+ current during depolarization in smooth muscle cells of the guinea‐pig vas deferens and urinary bladder

 almost abolished hot spots and markedly reduced IK,

Imaging caffeine-induced Ca2+ transients in individual fast-twitch and slow-twitch rat skeletal muscle fibers.

 greatly increased Ca2+ release and produced propagated waves of 

Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca.

 content was decreased by 9% after one pulse in 

 and by 21% after several pulses in caffeine.

Prostaglandin production by guinea-pig endometrial cells: effects of caffeine and other modulators of intracellular calcium.

 may therefore modulate the action of intracellular 

The inhibitory actions of caffeine and those of the compounds which interfere with the action of intracellular calcium were not additive, suggesting that

The effects of changes to action potential duration on the calcium content of the sarcoplasmic reticulum in isolated guinea-pig ventricular myocytes

 from the sarcoplasmic reticulum and this calcium is extruded from the cells by the sarcolemmal Na/Ca exchange.

Calcium mobilisation modulates growth of lens cells.

Characteristics of Ca2+ release mechanisms from an intracellular Ca2+ store in rabbit coronary artery.

The amplitude of contractile responses was much larger to the maximal stimulation of

 than to the maximal stimulation of IICR by applying IP3.

Properties of Ryr3 Ryanodine Receptor Isoform in Mammalian Brain (*)

Ryr3 demonstrated Ca-dependent [3H]ryanodine binding, and

Spontaneous and evoked oscillations of cytosolic calcium in the freshly prepared ciliary epithelial bilayer of the rabbit eye.

 transient and blocked spontaneous and (0.1 mM) muscarine induced oscillations.

Effects hypoxia/reoxygenation on intracellular calcium ion homeostasis in ventricular myocytes during halothane exposure.

They have an inability to be electrically paced following hypoxia and difficulty in handling large sudden increases in the 

Inhibitory effects of caffeine on secretagogue‐induced catecholamine secretion from adrenal chromaffin cells of the guinea‐pig

 (20 mm) caused an inhibition of catecholamine secretion evoked by 

Isoform-specific induction of nuclear free calcium oscillations by platelet-derived growth factor.

Caffeine alone had no effect on Ca2+n levels, but exposure of cells to

 oscillations, either by increasing the frequency or reinitiating preexisting oscillations.

Developmental toxicity of caffeine in the larvae of Xenopus laevis.

With regard to the pathogenesis of myofibril damage,

 appeared to cause a disturbance of intracellular calcium regulation, by 

 from the sarcoplasmic reticulum, and the mitochondrial changes observed in myotomal cells were considered to be reflective of this increased intracellular calcium ion levels.

Functional identification and quantitation of three intracellular calcium pools in GH4C1 cells: evidence that the caffeine-responsive pool is coupled to a thapsigargin-resistant, ATP-dependent process.

 release, and this action was observed even after complete depletion of the Tg-sensitive pool, indicating that pool 3 had the characteristics of a CICR compartment.

The effect of caffeine on the contractile response of the rabbit urinary bladder to field stimulation.

 significantly increased the rate of pressure generation at 0.6 and 1.8 mm 

The effect of prenatal caffeine exposure on the enamel surface of the first molars of newborn rats.

 and phosphorus contents of the first molars of the 

 were significantly higher than those of the control.

The effects of inhibitors of sarcoplasmic reticulum function on the systolic Ca2+ transient in rat ventricular myocytes.

The difference between caffeine and ryanodine is suggested to arise because

 potentiates Ca2+ release from the SR and thereby attenuates the effect of the decreased SR 

 content on the magnitude of the Ca2+ transient.

Twitch-dependent SR Ca accumulation and release in rabbit ventricular myocytes.

 in < 5 s (as assessed by a second Ccaf).

Caffeine and theophylline contractures in tonic skeletal muscle fibers of the frog.

 and theophylline promote the calcium release from sarcoplasmic reticulum and probably the entry of 

Caffeine inhibits the agonist-evoked cytosolic Ca2+ signal in mouse pancreatic acinar cells by blocking inositol trisphosphate production.

 signals evoked by ACh, cholecystokinin, and ATP and also inhibited signals generated in the absence of external Ca2+.

Mechanism of Ca2+ wave propagation in pancreatic acinar cells.

 and ryanodine, at concentrations that inhibit Ca(2+)-induced 

 (CICR), markedly slowed the speed of these waves.

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Research Papers that Mention the Interaction