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“Since a common mechanism of epilepsies and affective psychoses might be increased intracellular calcium ion levels, CBZ action was analyzed in penicillin, caffeine and low Mg2+ induced model epilepsies which have been shown to be suppressed specifically by organic calcium antagonists.”
European Neuropsychopharmacology • 1992 | View Paper
“ Caffeine contracture … calcium antagonists at 20 degrees C. This inhibition was caused by an early onset of relaxation, which was not observed at 7 degrees C. The … regulates E-C coupling but is not directly related to the functional calcium channel, may play an important role for the phenomena.”
“The inhibitory action of calcium antagonists on the caffeine contracture in the presence of calcium is probably independent of the potentiating effect seen in the depolarization-induced contractions.”
The Japanese journal of physiology • 1990 | View Paper
“Intake of several medications (e.g., betablockers, calcium channel blockers , theophylline derivatives), foods, and beverages containing caffeine should be abstained in order to maximize the pharmacologic effects of the vasodilator.”