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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
drug:
Atorvastatin
Research Papers that Mention the Interaction
“Although the atorvastatin dose in this study (10 mg/kg) was much higher than the maximum dose given to humans (80 mg), and although a pharmacokinetic interaction between caffeine and atorvastatin cannot be excluded, the findings of this study are of potential clinical importance.”
Wake Up and Smell the Coffee: Yet Another No Go for Cardiac Patients?“Results of the present study indicate treatment with the combination of caffeine and atorvastatin may be an effective strategy for inhibiting the growth of prostate cancer and should be evaluated clinically.”
“We found that atorvastatin and caffeine in combination downregulated phospho-Akt, phospho-Erk1/2, anti-apoptotic Bcl-2 and Survivin protein levels.”
“However, pretreatment of fundus strips with atorvastatin (3×10-5-3×10-4 M, 30 min) inhibited the contractions to calcium chloride (10-4-10-1 M), acetylcholine (10-4 M), and caffeine (20 mM) in the calcium-free medium.”
Relaxant effect of atorvastatin on isolated rat gastric fundus strips: implications for Ca2+-signalling mechanisms.
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