Possible Interaction: Caffeine and Antipsychotic Agents

“Patients under a neuroleptic treatment before admission presented a higher caffeine intake.”

“Although there was initial concern that caffeine might inactivate liquid doses of neuroleptics , the clinical significance of this concern is unclear.”

“Conclusions This case describes the interaction between a common caffeine-containing beverage and a commonly prescribed antipsychotic medication , associated with severe adverse effects.”

“We present two cases that show the ability of caffeine to induce psychotic and manic symptoms, and we also review the extant literature on caffeine-induced psychiatric manifestations.”

“During that year, he rejected anti-psychotic drugs but satisfactorily completed a psycho-educational programme while at the same time, consuming excessive amounts of alcohol and caffeine.”

“Conversely, in rare cases high doses of caffeine can induce psychotic and manic symptoms, and more commonly, anxiety.”

“ Psychotic patients have been reported to consume greater than average amounts of caffeine.”

“Thus, caffeine can interact with a wide range of psychiatric medications, including antidepressant agents, antipsychotic agents , antimanic agents, antianxiety agents, and sedative agents.”

“1965) Furthermore, there is evidence … suggest that the effect of caffeine in psychiatric patients could be an … one through the interference with antipsychotic drug effect (Kulhanek, Linde, & Meisenberg, 1979) The experimental research described here was double blind … controlled for body weight and usual consumption, and used three dosage levels”

“First, caffeine was shown to interact in vitro with a number of neuroleptics to form flaky precipitates and thus possibly impair the efficacy of these agents.8,9 Second, caffeine clinically antagonizes barbiturates” and monoamine oxidase inhibitors (MAOI).””