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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Caffeine
Research Papers that Mention the Interaction
“This led to the study of caffeine , that displayed effective dose-related inhibition of the mutagenicity of PhIP.”
Inhibition of PhIP mutagenicity by caffeine, lycopene, daidzein, and genistein.“In a metabolic activation study of PhIP , HTHQ and caffeine clearly inhibited the formation of metabolites.”
Chemoprevention of heterocyclic amine‐induced mammary carcinogenesis in rats“Ten weeks concurrent administration of caffeine (1000 ppm) and PhIP (400 ppm) resulted in significant increase of colon ACFs and CYP1A2 expression.”
“Surprisingly, metabolic activation of PhIP was inhibited by addition of caffeine in an in vitro assay.”
“The final combined incidences (adenomas plus adenocarcinomas) and multiplicity (No./rat) of mammary adenomas and adenocarcinomas were significantly lowered in the PhIP plus caffeine group (10%, 0.10) as compared to the PhIP alone value (40%, 0.50).”
“With regard to colon tumor development, on the other hand, rats given PhIP plus caffeine exhibited an elevated incidence (75% versus 15% in the control), whereas α‐tocopherol and TTAD had no effect.”
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