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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Butylated Hydroxytoluene
drug:
Urethane
Research Papers that Mention the Interaction
“ BHT administration increased the multiplicity of hyperplasias observed 3 weeks after the urethane injection and additionally caused adenomas which did not occur in the urethane alone-treated animals.”
Susceptibility to urethane carcinogenesis of transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) and its modification by butylhydroxytoluene.“Tumor multiplicity increased if BHT administration followed urethane exposure, showing that a Chr 6 gene(s) regulates sensitivity to chemically‐induced tumor promotion.”
Epistatic interactions govern chemically‐induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J‐ChrA/J chromosome substitution strains“A/J mice given urethan (1000 mg/kg) followed by four injections of butylated hydroxytoluene (BHT) (400 mg/kg) developed within 4 mo approximately 40% more lung tumors than mice treated with urethan and given four injections of corn oil.”
“Administration of BHT can be delayed up to 5 months after urethan treatment and still enhance tumor formation.”
“Increased numbers of tumors per lung were also found when the interval between urethan injection and the first BHT treatment was extended up to 6 weeks.”
“Repeated treatment with BHT, followed by urethan, had no effect and concomitant administration of urethan and BHT reduced the number of tumors found.”
“When urethan was followed by weekly ip administrations of butylated hydroxytoluene (BHT), the number of tumors per lung found 14 to 24 weeks after urethan was increased.”
“If BHT was given orally following injection of one single dose of urethane , adenoma formation in lung was enhanced.”
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