Possible Interaction: Butylated Hydroxytoluene and Prednisolone

“Recent work has shown … 30 mg/kg prednisolone to mice, twice daily on days … the induction of lung damage with butylated hydroxytoluene (BHT), results in the development of a more severe fibrotic lesion [J.P. Kehrer, …. Klein-Szanto, E. M. B. Sorensen, R. Pearlman and M. H. Rosner, Am.”

“This inhibition was maintained by twice daily doses of prednisolone on Days 1 to 5 after BHT , and was followed by a rebound in DNA synthesis on Day 7.(ABSTRACT TRUNCATED AT 250 WORDS)”

“Treatment with the corticosteroid prednisolone , 30 mg/kg twice daily during the first 5 days after BHT , greatly exacerbated the initial damage.”

“ Prednisolone 50 and 100 micrograms/ml also inhibited the rate of collagen synthesis in lung tissue obtained 3 days after BHT but, in addition, decreased the percentage of protein synthesis committed to collagen.”

“Seven days after BHT, prednisolone increased both the rate and percentage of pulmonary collagen synthesis.”

“Administering prednisolone (60 mg/kg/day) on days 1-6 after BHT to mice left in room air produced significantly more pulmonary fibrosis than in BHT-treated mice given saline.”

“The administration of prednisolone (60 mg/kg/day) on days 1-3, 1-6, or 4-6 after BHT decreased mortality but had no effect on accumulation of lung collagen.”