Possible Interaction: Butylated Hydroxytoluene and Norepinephrine

“ Abstract Butylated hydroxytoluene (BHT), a widely used antioxidant food preservative, has been found to be a potent inhibitor of norepinephrine uptake into synaptic vesicles isolated from rat brain.”

“The same levels of BHT which inhibited neurotransmitter transport also caused a significant increase in the fluorescence polarization … the membrane probe 1,6-diphenyl-1,3,5-hexatriene embedded in synaptic vesicle membranes, suggesting that BHT may block transport indirectly by … the transmembrane mobility of a norepinephrine carrier protein.”