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Last Updated: 2 years ago

Possible Interaction: Butylated Hydroxytoluene and Glutathione

Research Papers that Mention the Interaction

These findings proved that BHT inhibits Hg2+-toxicity, hindering ROS generation and intrinsic apoptosis, via enhancing glutathione and antioxidants; and suggested BHT implications as therapeutic.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2020  |  View Paper
Both TB and BHT induced GSH S-transferase activities towards a range of substrates.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2004  |  View Paper
Whereas all compounds produced a drastic decrease of the mutagenic activity, the first three only (quercetin, beta-naphthoflavone, butylated hydroxytoluene ) interfered with the production of the adducts to glutathione.
Journal de la Societe de biologie  •  2000  |  View Paper
BHT feeding to rats at a dose of 0.75% for 15 days caused a significant increase in the GSH S-transferase activity.
Cancer letters  •  1997  |  View Paper
BHT had a dose-dependent effect on GSH levels of lenses in cultures.
Inclusion of 10 microM BHT in the culture medium resulted in a twofold increase in GSH levels of the lens within 24 hr.
Increased gamma-glutamylcysteine synthetase activity concomitant with the increased amount of [35S]methionine incorporation in GSH strongly suggested that BHT caused enhanced levels of GSH in lenses by increasing de novo biosynthesis.
Oral administration of BHT to rats also resulted in enhanced in vivo levels of GSH in lens, retina and cornea.
Experimental eye research  •  1992  |  View Paper
Mice … BHT (200-800 mg/kg, po) in … with an inhibitor of glutathione ( GSH ) synthesis, buthionine sulfoximine (BOS; 1 hr before and 2 hr after BHT, 4 mmol/kg per dose, ip) … hepatotoxicity characterized by an increase in serum glutamic pyruvic transaminase (GPT) activity and centrilobular necrosis of hepatocytes.
Toxicology and applied pharmacology  •  1987  |  View Paper
The time course of the liver glutathione content between single doses of 100 mg/kg BHA or BHT revealed an initial decline followed by an increase above control values 2 days (BHA) or 5 days (BHT) after the first application.
Toxicology  •  1986  |  View Paper
It is suggested that the differential induction of GSH S-transferase activities by BHT towards different substrates may be due to the differences in the induction of the constituent subunits of GSH S-transferases.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1984  |  View Paper
In a separate experiment, consistently higher baseline concentrations of reduced glutathione were observed in BHT-pretreated cells, indicating that BHT pretreatment may enhance formation of detoxified glutathione conjugates of AFB1.
Toxicology and applied pharmacology  •  1984  |  View Paper
BHT administration to mice produced a time-dependent reduction of glutathione (GSH) content in the lung, but not in the liver.
Toxicology letters  •  1984  |  View Paper
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