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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Butylated Hydroxytoluene
drug:
Factor Ix
Research Papers that Mention the Interaction
“The plasma concentrations of factors II, VII, IX and X were significantly reduced in a time-dependent fashion when BHT was administered for 2–7 days and haemorrhages in epididymis were found in rats given BHT for 4–7 days.”
“These results suggest that factors II, VII, IX and X rapidly decrease immediately after the administration of BHT , but hypoaggregability of washed platelets reported previously may be a secondary defect caused by bleeding.”
Feeding of butylated hydroxytoluene to rats caused a rapid decrease in blood coagulation factors II (prothrombin), VII, IX and X“Levels of factors II, VII, X and IX were reduced 36-60 hr after BHT treatment, but by 72 hr, those most affected (VII and IX) showed some recovery and X had returned to normal.”
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