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Last Updated: 2 years ago

Possible Interaction: Butylated Hydroxytoluene and Buthionine Sulfoximine

Research Papers that Mention the Interaction

Pretreatment with buthionine sulfoximine (BSO; 900 mg/kg) induced the elevation of serum GOT and GPT activities in a non-toxic dose of butylated hydroxytoluene (BHT; 250-500 mg/kg) in rats.
Toxicology letters  •  1987  |  View Paper
Mice … BHT (200-800 mg/kg, po) in combination … an inhibitor of glutathione (GSH) synthesis, buthionine sulfoximine (BOS; 1 hr before and 2 hr after BHT, 4 mmol/kg per dose, ip) developed … characterized by an increase in serum glutamic pyruvic transaminase (GPT) activity and centrilobular necrosis of hepatocytes.
Toxicology and applied pharmacology  •  1987  |  View Paper
Treatment of mice with diethyl maleate (DEM) or buthionine sulfoximine (BSO) significantly enhanced the lung injury caused by butylated hydroxytoluene (BHT).
Toxicology letters  •  1984  |  View Paper