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Last Updated: 3 years ago
supplement:
Butylated Hydroxytoluene
Research Papers that Mention the Interaction
“Pretreatment with buthionine sulfoximine (BSO; 900 mg/kg) induced the elevation of serum GOT and GPT activities in a non-toxic dose of butylated hydroxytoluene (BHT; 250-500 mg/kg) in rats.”
Effects of buthionine sulfoximine and cysteine on the hepatotoxicity of butylated hydroxytoluene in rats.“Mice … BHT (200-800 mg/kg, po) in combination … an inhibitor of glutathione (GSH) synthesis, buthionine sulfoximine (BOS; 1 hr before and 2 hr after BHT, 4 mmol/kg per dose, ip) developed … characterized by an increase in serum glutamic pyruvic transaminase (GPT) activity and centrilobular necrosis of hepatocytes.”
“Treatment of mice with diethyl maleate (DEM) or buthionine sulfoximine (BSO) significantly enhanced the lung injury caused by butylated hydroxytoluene (BHT).”
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