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Last Updated: 4 months ago

Possible Interaction: Butorphanol and Cocaine



Research Papers that Mention the Interaction

On the PR schedule, amphetamine and butorphanol non-significantly decreased cocaine self-administration when administered alone but significantly decreased cocaine self-administration when administered in combination.
Behavioural Brain Research  •  2014  |  View Paper
ConclusionsThese data suggest that low-efficacy opioids possessing significant mu-agonist activity (e.g. buprenorphine, butorphanol , nalbuphine, (−)-pentazocine) may potentiate the effects of cocaine in a manner similar to that typically observed with high-efficacy mu opioids.
The high-efficacy mu opioid levorphanol, and the low-efficacy opioids buprenorphine, butorphanol , nalbuphine and (−)-pentazocine, dose-dependently enhanced the effects of cocaine at doses that did not alter locomotor activity when administered alone.
Psychopharmacology  •  2003  |  View Paper
Nalbuphine and butorphanol produced the greatest decreases in cocaine self-administration and the smallest effects on food-maintained responding.
The Journal of pharmacology and experimental therapeutics  •  2002  |  View Paper
Buprenorphine, butorphanol and nalbuphine tested against the optimal unit dose of cocaine (0.8 microg per infusion), inhibited initiation of cocaine self-administration in a dose-dependent manner.
European Neuropsychopharmacology  •  2000  |  View Paper
Butorphanol pretreatment (8 mg/kg) suppressed cocaine self-administration and blocked the effect of the cocaine priming injections on pretreatment testing days.
Experimental and clinical psychopharmacology  •  1998  |  View Paper
Both nalbuphine and butorphanol reduced cocaine self-administration (p < 0.0001) but this effect was not selective since food self-administration also decreased in a dose-dependent manner (p < 0.0001).
Neuropsychopharmacology  •  1993  |  View Paper