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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Butorphanol
supplement:
Cocaine
Research Papers that Mention the Interaction
“ConclusionsThese data suggest that low-efficacy opioids possessing significant mu-agonist activity (e.g. buprenorphine, butorphanol , nalbuphine, (−)-pentazocine) may potentiate the effects of cocaine in a manner similar to that typically observed with high-efficacy mu opioids.”
“The high-efficacy mu opioid levorphanol, and the low-efficacy opioids buprenorphine, butorphanol , nalbuphine and (−)-pentazocine, dose-dependently enhanced the effects of cocaine at doses that did not alter locomotor activity when administered alone.”
Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor“Buprenorphine, butorphanol and nalbuphine tested against the optimal unit dose of cocaine (0.8 microg per infusion), inhibited initiation of cocaine self-administration in a dose-dependent manner.”
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