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Last Updated: 3 years ago

Possible Interaction: Buthionine Sulfoximine and Sulforaphane

drug:

Buthionine Sulfoximine

supplement:

Sulforaphane

Research Papers that Mention the Interaction

“Moreover, exposure to L-buthionine-sulfoximine , an irreversible inhibitor of γ-GCS, suppressed the protective effects of sulforaphane and 6-HITC.”
Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate.
Journal of pharmacological sciences  •  2011  |  View Paper
“The protective effect of SFN on ROS production and cell viability was prevented by buthionine sulfoximine (BSO), an inhibitor of γGCL, and by dicoumarol, an inhibitor of NQO1.”
Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells.
Toxicology letters  •  2010  |  View Paper
“In Nrf2(+/+) MEFs pre-treated with sulforaphane, BSO diminished intrinsic resistance and abolished inducible resistance to acrolein, CuOOH and chlorambucil, but not menadione.”
Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.
Toxicology and applied pharmacology  •  2009  |  View Paper
“Furthermore, the use of BSO to decrease intracellular GSH levels further enhanced the effects of SFN.”
Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells.
Vascular pharmacology  •  2008  |  View Paper