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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Furthermore, in cells pretreated with L-BSO , the addition of ascorbate (250 microM) afforded significant protection against DA-induced toxicity, while pyruvate (500 microM) had no protective effect.”
Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by l-BSO and apoptosis“Buthionine sulfoximine (BSO) was given intravitreally; at 48 hours after 4.0 mg BSO , iris-ciliary body total glutathione levels were reduced by 80%, aqueous ascorbate levels were reduced by 53%, and aqueous H2O2 levels were unaltered.”
The effects of ascorbate, 3-aminotriazole, and 1,3-bis-(2-chloroethyl)-1-nitrosourea on hydrogen peroxide levels in the rabbit aqueous humor.“ BSO affected the transcription and activities of key enzymes involved in ascorbate metabolism, which resulted in major fluctuations in cellular ascorbate levels.”
Buthionine sulfoximine (BSO)-mediated improvement in cultured embryo quality in vitro entails changes in ascorbate metabolism, meristem development and embryo maturation
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