Possible Interaction: Busulfan and Serum Albumin, Human

“HSA fluorescence quenching experiments showed that BN reduces the HSA native fluorescence intensity through the static mechanism.”

“Ligand binding site to HSA was further investigated by site-specific markers in fluorescence measurements as well molecular modeling approach which indicated that BN bind to the nearby sudlow site II of HSA through hydrophobic as well as hydrogen bonding interaction.”

“Moreover, the secondary structure alteration of HSA following its complexation with BN was studied and showed that α-helical content of HSA gets increased on interacting with BN.”