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Last Updated: 4 months ago

Possible Interaction: Buspirone and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

CONCLUSIONS The results suggest that buspirone is unlikely to have a beneficial effect on preventing relapse to cocaine use and that buspirone for cocaine-dependent women may worsen their cocaine use outcomes.
The Journal of clinical psychiatry  •  2014  |  View Paper
Two such drugs, lorcaserin (Belviq; a drug with serotonin [5-HT]2C receptor agonist properties) and buspirone (Buspar; a drug with 5-HT1A receptor partial agonist and dopamine D3/D4 receptor antagonist properties) can produce modest decreases in cocaine self-administration in rhesus monkeys.
Experimental and clinical psychopharmacology  •  2018  |  View Paper
Buspirone significantly reduced responding maintained by cocaine , and shifted the dose–effect curve downwards.
These findings indicate that buspirone selectively attenuates the reinforcing effects of cocaine in a nonhuman primate model of cocaine self-administration, and has variable effects on cocaine discrimination.
Neuropsychopharmacology  •  2013  |  View Paper
Overall, these results suggest that buspirone may reduce the likelihood of relapse to cocaine and methamphetamine use under some conditions, although this speculation must be interpreted with caution given buspirone's similar potency to attenuate inactive-lever responding.
RESULTS Buspirone (1 and 3mg/kg) significantly (p<0.05) attenuated cocaine cue but not cocaine prime reinstatement.
Drug and alcohol dependence  •  2013  |  View Paper
In tests for conditioning, however, the effects of buspirone and MK-801 depended upon their association with cocaine.
Behavioural Brain Research  •  1999  |  View Paper
The ability of buspirone , but not gepirone, to attenuate the cocaine stimulus probably reflects its dopamine (DA) D2 receptor antagonist properties and not its efficacy at 5-HT1A receptors.
Neuropharmacology  •  1997  |  View Paper
Thus, behaviorally active doses of buspirone failed to attenuate the discriminative stimulus effects of cocaine in a sensitive behavioral paradigm.
Pharmacology Biochemistry and Behavior  •  1993  |  View Paper
Acute pretreatment with buspirone (0.1 and 0.3 mg/kg, IV) increased rates of cocaine self-administration without disrupting food pellet consumption.
Psychopharmacology  •  1992  |  View Paper