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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bupropion
supplement:
St John's Wort
Research Papers that Mention the Interaction
“Case reports or case series suggest interactions of St John’s wort with adrenergic vasopressors, anaesthetics, bupropion , buspirone, ciclosporin, eletriptan, loperamide, nefazodone, nevirapine, oral contraceptives, paroxetine, phenprocoumon, prednisone, sertraline, tacrolimus, theophylline, tibolone, tryptophan, venlafaxine and warfarin.”
Interactions Between Herbal Medicines and Prescribed Drugs“ St. John’s wort decreased, to a statistically significant extent, the plasma concentrations of bupropion , probably mainly by increasing the clearance of bupropion.”
“ St. John’s wort treatment increased the oral clearance of bupropion from 108.3 l h−1 (95% CI = 95.4–123.0 l h−1) to 130.0 l h−1 (95% CI = 118.4–142.7 l h−1).”
“It is not recommended to use St John's Wort in combination with bupropion [2].”
“We report the case of a patient who developed a persistant dystonia following bupropion , used in association with St John's Wort.”
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