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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Buprenorphine
supplement:
Marijuana
Research Papers that Mention the Interaction
“Of the concurrent use of marijuana and cocaine with buprenorphine , cocaine is most concerning since it decreases exposure to buprenorphine (lower area under the concentration-time curve and maximum concentration).”
Urine specimen detection of concurrent nonprescribed medicinal and illicit drug use in patients prescribed buprenorphine.“ Cannabis users and non-users received similar doses, but users had 2.7-fold higher concentrations of buprenorphine ( p < 0.01) and 1.4-fold for norbuprenorphine (1.4-fold, p = 0.07).”
“These findings indicate that cannabis use decreases the formation of norbuprenorphine and elevates buprenorphine and norbuprenorphine concentrations in blood most probably by inhibition of CYP3A4.”
Buprenorphine–cannabis interaction in patients undergoing opioid maintenance therapy
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