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Last Updated: 2 years ago

Possible Interaction: Buprenorphine and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

Interestingly, with a higher dose of buprenorphine (6 mg), cocaine may have increased opiate withdrawal symptoms, suggesting a possible mechanism for the reduction of illicit cocaine abuse also recently observed in another study in patients treated with high dose (120 mg) methadone maintenance.
The American journal of drug and alcohol abuse  •  1994  |  View Paper
This reduction from Day 3 to Day 5 suggests that cocaine may interact differently with buprenorphine as treatment is more prolonged.
The American journal of drug and alcohol abuse  •  1993  |  View Paper
In fact, the mOR agonists methadone and buprenorphine decrease cocaine self-administration in laboratory animals (10), and in clinical studies, buprenorphine has been shown to reduce cocaine use in dually dependent cocaine/heroin abusers (reviewed in McCann [11]).
Biological Psychiatry  •  2010  |  View Paper
Recent preclinical studies have shown that buprenorphine also significantly reduces cocaine self‐administration by rhesus monkeys for periods up to 120 days.
Harvard review of psychiatry  •  1993  |  View Paper
Veterans with cocaine and anxiolytic-sedative hypnotic use disorders had higher odds of being started on both buprenorphine and methadone compared with no OAT.
Substance abuse  •  2019  |  View Paper
Cocaine decreases methadone and buprenorphine plasma concentrations.
Journal of substance abuse treatment  •  2015  |  View Paper
Of the concurrent use of marijuana and cocaine with buprenorphine , cocaine is most concerning since it decreases exposure to buprenorphine (lower area under the concentration-time curve and maximum concentration).
Journal of analytical toxicology  •  2013  |  View Paper
The use of cocaine by heroin-dependent individuals, or by patients in methadone or buprenorphine maintenance treatment, is substantial and has negative consequences on health, social adjustment and outcome of opioid-addiction treatment.
Addiction  •  2003  |  View Paper
Although buprenorphine appears to reduce cocaine self-administration in studies of non-opiate dependent animals, clinical evidence for the same response in opiate addicts abusing cocaine has not been demonstrated.
Journal of addictive diseases  •  1995  |  View Paper
Preclinical studies in both primates and rodents have also indicated that buprenorphine may reduce cocaine self-administration and attenuate place preference for cocaine.
Psychopharmacology bulletin  •  1992  |  View Paper
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