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Discover Supplement-Drug Interactions

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Possible Interaction: Bupranolol and Quinidine

supplement:

Quinidine

Research Papers that Mention the Interaction

The enzyme catalysing bupranolol metabolism was CYP2D6: microsomes from a liver with the genetic enzyme deficiency did not metabolize bupranolol; in microsomes from livers containing the enzyme and 10 μM bupranolol, 5 μM quinidine caused a 72% inhibition of bupranolol metabolism.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
Quinidine competitively inhibited the formation of hydroxybupranolol , with Ki values of 5 nM in expressed CYP2D6 and 14.05 nM in human liver (L-1).
Drug metabolism and disposition: the biological fate of chemicals  •  1996  |  View Paper