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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bupranolol
supplement:
Quinidine
Research Papers that Mention the Interaction
“The enzyme catalysing bupranolol metabolism was CYP2D6: microsomes from a liver with the genetic enzyme deficiency did not metabolize bupranolol; in microsomes from livers containing the enzyme and 10 μM bupranolol, 5 μM quinidine caused a 72% inhibition of bupranolol metabolism.”
Interactions of bupranolol with the polymorphic debrisoquine/sparteine monooxygenase (CYP2D6)“ Quinidine competitively inhibited the formation of hydroxybupranolol , with Ki values of 5 nM in expressed CYP2D6 and 14.05 nM in human liver (L-1).”
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