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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bupranolol
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ Bupranolol stimulated the disaggregation of platelet aggregates induced by a combination of adrenaline and ADP, but propranolol did not.”
“With human platelets, aggregation induced by adrenaline was inhibited by bupranolol about 2.8-3.3 times as effectively as propranolol.”
Effects of bupranolol, a new beta-blocker, on platelet functions of rabbit and human in vitro.“The concentration-response curve for adrenaline was shifted rightwards in a competitive fashion by the beta(1)-/beta(2)-nonselective antagonists propranolol and bupranolol , with pA(2) values of 8.85 and 8.97, respectively.”
Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of beta(2)-adrenoceptors.“The effect of adrenaline on Isc was augmented by the adrenoceptor antagonists prazosin (α1, 10−4 M) and bupranolol (β, 10−6 M), but inversed by yohimbine (α2, 10−5 M).”
“ Bupranolol (10(-4) M) significantly decreased the cyclic AMP level that was elicited by epinephrine , whereas propranolol (10(-5) M) produced no effect.”
“The response to epinephrine was antagonized in a concentration dependent manner by bupranolol , and Schild plot of the data revealed the pA2 value of 5.87.”
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