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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bupivacaine
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“The authors conclude that the addition of sodium bicarbonate to bupivicaine reduces the pain associated with its local infiltration.”
“The authors propose that pH buffering of bupivicaine with sodium bicarbonate reduces the pain associated with its local subcutaneous infiltration.”
The effect of pH buffering on reducing the pain associated with subcutaneous infiltration of bupivicaine.“Thus, pH adjustment of a solution of bupivacaine and hyaluronidase with sodium bicarbonate hastens the onset time and improves the initial success rate of peribulbar block.”
“The addition of sodium bicarbonate as a buffering agent to the local anesthetics lidocaine and bupivacaine can significantly reduce pain upon injection.”
“Injection of sodium bicarbonate into the limb 10 min before the release of the tourniquet suppressed the rate at which the concentration of bupivacaine decreased during the second phase.”
Effect of sodium bicarbonate on the kinetics of bupivacaine in i.v. regional anaesthesia in dogs.“ Sodium bicarbonate has been reported to hasten epidural onset of chloroprocaine, lidocaine and bupivacaine while tris(hydroxymethyl) aminomethane (THAM) has been shown to delay the onset of epidurally administered chloroprocaine in parturients.”
Does the addition of tris(hydroxymethyl) aminomethane to 0.5% bupivacaine delay epidural onset in parturients?“However, addition of sodium bicarbonate to commercially manufactured bupivacaine can rapidly produce precipitation.”
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