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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Bupivacaine
supplement:
Quinidine
Research Papers that Mention the Interaction
“The addition of diphenylhydantoin, quinidine , pethidine, desipramine, but not atropine, to normal plasma also caused marked displacement of bupivacaine.”
Plasma protein binding of bupivacaine and its interaction with other drugs in man.“Co-administration of bupivacaine with flecainide, quinidine , or mexiletine displayed an additive effect on spinal blockades of motor function and nociception.”
“We concluded that bupivacaine combined with flecainide, quinidine , or mexiletine exhibited an additive effect on spinal blockades of motor function and nociception.”
Spinal blockades of class I antiarrythmic drugs with bupivacaine by isobolographic analysis in rats“ConclusionThese results suggest that quinidine inhibited P-gp activity, resulting in increased brain/plasma concentration ratio of bupivacaine , but not of lidocaine, and decreased the threshold of plasma concentration for bupivacaine-induced convulsions.”
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