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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bupivacaine
supplement:
Progesterone
Research Papers that Mention the Interaction
“Pregnancy is known to increase myocardial susceptibility to bupivacaine-induced cardiovascular collapse, and prolonged pretreatment of rabbits with high doses of progesterone potentiates bupivacaine's depression of the maximal rate of increase (Vmax) of the cardiac action potential.”
Beta-estradiol acutely potentiates the depression of cardiac excitability by lidocaine and bupivacaine.“Progesterone levels are elevated during pregnancy, and exogenously increasing progesterone levels in rabbits has increased bupivacaine's depressive effects on excitability.”
“These results indicate that progesterone selectively increases the cardiac membrane depressant effects of bupivacaine but not lidocaine.”
“Each concentration of progesterone (6.25, 12.5, 25, and 50 μg/ml) caused a significant and concentration-dependent reduction in the AD50 for bupivacaine.”
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