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“Forced vital capacity … decreased with bupivacaine (3.6+/-0.5 L … 3.5+/-0.4 L , P<0.05) and ropivacaine (3.2+/-0.4 L to 3.1+/-0.5 L, P<….05), but not with levobupivacaine (3.6+/-0.5 L to 3.4+/-0.6 L).”
“The activity of potent proteolytic enzyme, cathepsins B and L (assayed against a new synthetic substrate succinyl-Tyr-Met-naphthylamide), gradually increased and reached a plateau value that was 11-fold greater than the control 48 h after bupivacaine injection.”
“Forced vital capacity was significantly decreased with bupivacaine (3.0 ± 0.4 L to 2.7 ± 0.3 L , P < 0.05) and ropivacaine (2.9 ± 0.4 L to 2.5 ± 0.4 L, P < 0.05) while there were no difference between two groups.”