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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bupivacaine
supplement:
Intralipid
Research Papers that Mention the Interaction
“However, both Intralipid and Lipofundin partly relieve Nav1.5 from block by bupivacaine.”
The Distinct Effects of Lipid Emulsions Used for “Lipid Resuscitation” on Gating and Bupivacaine-Induced Inhibition of the Cardiac Sodium Channel Nav1.5“To conclude, 4 mL/kg of Intralipid expedited cardiovascular recovery from bupivacaine cardiotoxicity mainly by increasing systemic vascular resistance.”
The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs“One of the mechanism of the beneficial effects was probably that Intralipid injection increases the apparent volume of bupivacaine distribution and that decreases blood concentration. [”
“Recent case reports have suggested that Intralipid (Fresenius Kabi) is an effective therapy for cardiac toxicity from high systemic concentrations of, e.g. bupivacaine , even though the mechanism behind the interaction is not fully clear yet.”
Liposomes for entrapping local anesthetics: A liposome electrokinetic chromatographic study
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