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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bupivacaine
supplement:
Glucose
Research Papers that Mention the Interaction
“Although there was no difference between groups in … of ephedrine or patient satisfaction, patients receiving bupivacaine (5 … glucose (8 mg ml(-1)) had persistently higher sensory blocks between 60 and 120 min after intrathecal … spread of spinal solutions in the pregnant patient at term is not dependent on density.”
“However, the addition of only a small amount of glucose (8 mg ml(-1)) to plain solutions of bupivacaine results in a solution which, although no more than marginally hyperbaric, produces a more predictable block when used for spinal anaesthesia in non-pregnant patients.”
Spinal anaesthesia for Caesarean section with bupivacaine 5 mg ml(-1) in glucose 8 or 80 mg ml(-1).“ Bupivacaine is rendered hyperbaric by adding glucose.”
“Implications: Dextrose alters the density of intrathecal bupivacaine solutions and is thought to influence subarachnoid distribution of the drug.”
“In this study, human neuroblastoma (SH-SY5Y) cells were cultured with high glucose and/or bupivacaine, and the data showed that high glucose enhanced bupivacaine-induced MCU expression elevation, mCa2+ accumulation, and oxidative damage.”
“In all groups, levels of ROS production, cell survival and GRP78 expression were significantly different (P<0.01) following the addition of various concentrations of glucose and bupivacaine , as well as for the interaction between different concentrations of the anesthetic agents, demonstrating a statistically significant difference.”
“The effect, duration and complications of subarachnoid anesthesia with hyperbaric bupivacaine solution , adjusted at a gravity of 1.044 and 1.033 by adding glucose , were compared with those of isobaric 0.5% bupivacaine anesthesia.”
“The effects are retarded in the presence of glucose and are higher and more rapid for the carbonized form of bupivacaine (CO2 form instead of hydrochloride form).”
“The mean time between subarachnoid injection and the time when Cmax was reached (tpeak) was influenced by the density of bupivacaine, i.e., the tpeak of bupivacaine with glucose was significantly shorter than with glucose-free solution (35 min; P < 0.05).”
“ Bupivacaine 0.75% (3 ml, 22.5 mg) in solution with glucose produced a more marked effect on the blood pressure than the other solutions tested.”
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