Possible Interaction: Bumetanide and Selenium

“ Bumetanide (500 microM), an inhibitor of chloride secretion in other systems, decreased the basal psi t from -5 +/- 1.5 to -3.2 +/- 1.6 ( SE ) mV (P less than 0.05, n = 6), suggesting that chloride transport contributed to the voltage.”

“CPT-cAMP, 50 microM) and 3-isobutyl 1-methylxanthine (IBMX, 100 microM) had similar effects, causing … increase in the psi t from -2.2 +/- 0.5 to -8 +/- 1.6 SE ) mV, an effect that was inhibited by the addition of bumetanide (P less than 0.005, n = 6).”