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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bumetanide
supplement:
Genistein
Research Papers that Mention the Interaction
“Finally, the NKCC1 inhibitor, bumetanide fully antagonized the vasorelaxant responses to genistein against phenylephrine- or KCl-induced contractions, with IC50=2.0+/-0.2 microM and 1.6+/-0.5 microM, respectively (n=6 for condition).”
Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta.“The secretory effect of genistein was dependent on the presence of Cl- and was blocked by inhibitors of Cl- secretion like bumetanide , an inhibitor of the Na(+)-K(+)-Cl- cotransporter, or 5-nitro-2-(3- phenylpropylamino)-benzoate (NPPB), a Cl- channel blocker.”
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