“The treatment of RDs needs extra attention as hydroxychloroquine requires more frequent monitoring for adverse drug reactions; … necessary for mycophenolate mofetil, cyclosporine A, and tacrolimus; cyclophosphamide and azathioprine need dose adjustments; methotrexate and bucillamine are contraindicated in patients with ESRD; leflunomide … not require significant dose reduction and iguratimod should ….”