Possible Interaction: Bryostatin 1 and Dolastatin 10

“We conclude that: (i) auristatin … effective in this model than dolastatin 10 , vincristine or bryostatin 1, (ii) auristatin PE can be administered at a concentration 10 … dolastatin 10, and (iii) there is a synergistic effect between these agents and bryostatin 1 , which is more apparent … 1 + auristatin PE combination.”

“Cells pretreated with Bryo1 and then exposed to Dol10 showed an increase in apoptosis compared with cells that were treated with the Dol10, Dol15 alone.”