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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bromodeoxyuridine
supplement:
Caffeine
Research Papers that Mention the Interaction
“ Caffeine and okadaic acid, both established radiosensitizers, inhibit the incorporation of BrdU in G2 cells.”
Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells“1) Continuous post-UV treatment with 1 mM caffeine markedly enhances UV-induced SCEs and such enhanced SCEs occur with similar frequency during either the 1st or the 2nd cell cycle in the presence of caffeine and 5-bromodeoxyuridine (BrdUrd). (”
“… CAF was added to the … the presence of BrdU and then the cultures treated with MC, M-MC, 4NQO or EMS during the second cell cycle, the effect of …., the SCE level achieved was much higher than that expected from a simple additive effect of the agents and CAF.”
“Thus exposure to caffeine reveals a persistent sensitivity lasting for at least two cell cycles, after the injury induced by treatment with BrdUrd and UVB.”
Caffeine-induced apoptosis reveals a persistent lesion after treatment with bromodeoxyuridine and ultraviolet-B light.“Interestingly, theophylline had a suppressive effect on cellular proliferation, whereas caffeine enhanced cellular proliferation rates via the 5-bromo-2-deoxyuridine analysis.”
Theophylline exhibits anti-cancer activity via suppressing SRSF3 in cervical and breast cancer cell lines
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