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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bromocriptine
supplement:
Oxytocin
Research Papers that Mention the Interaction
“Neither pirenzepine nor trimethaphan administration changed the oxytocin response to hypoglycemia, whereas bromocriptine significantly reduced the oxytocin increase during the ITT.”
Dopaminergic, but not cholinergic, involvement in regulation of hypoglycemia-induced oxytocin release in man“Finally, both bromocryptine and the OTA suppressed oxytocin mRNA expression and prolactin replacement restored expression levels to that of controls.”
Prolactin and Oxytocin Interaction in the Paraventricular and Supraoptic Nuclei: Effects on Oxytocin mRNA and Nitric Oxide Synthase“Addition of oxytocin (5x10(-12)-4x10(-11) m) to the uterus isolated from rats pretreated with bromocriptine resulted in marked uterotonic effect (24, 35 and 49% increase in F; 25, 35 and 46% increase in A and 42, 62 and 122% increase in AUC of contractions).”
“In addition, this must be considered when using oxytocin during delivery of females pretreated with bromocriptine.”
“Stimulation of the D-2 DA receptor with PPHT had no effect on basal OT release in nonsuckled rats, but this agent, as well as another D-2 DA agonist, bromocriptine , prevented the suckling-induced release of both OT and PRL.”
“In a third study, the increase in plasma OT in response to suckling was prevented by stimulation of DA receptors with bromocriptine , while blockade of DA receptors with domperidone significantly increased plasma OT levels in nonsuckled lactating rats.”
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