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Last Updated: 2 years ago

Possible Interaction: Bromocriptine and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

The question of whether bromocriptine will reduce the use of cocaine or promote entry into drug treatment deserves further research.
Journal of General Internal Medicine  •  2007  |  View Paper
Bromocriptine pretreatment diminished blood pressure generally, including cocaine-induced blood pressure increases, and augmented the heart rate after cocaine.
suggested that bromocriptine may decrease the urge to use cocaine that was evoked by cocaine itself.
Pharmacology Biochemistry and Behavior  •  1989  |  View Paper
It is hypothesized that bromocriptine , a dopamine agonist, will reduce a patient's craving for cocaine and simultaneously address the patient's ADD-RT symptoms.
Journal of psychoactive drugs  •  1989  |  View Paper
Caution is advised when there is additional recent use of cocaine because of a suggested potentiating action of cocaine on the development of adverse cardiovascular and cerebral sequelae in postpartum patients who take bromocriptine.
American journal of obstetrics and gynecology  •  1990  |  View Paper
There have now been reports that bromocriptine may reduce postwithdrawal craving for cocaine , but these first reports need to be investigated further.
The Medical journal of Australia  •  1969  |  View Paper
In some instances, low doses of bromocriptine decreased responding maintained by cocaine without reducing food-maintained responding, while higher doses of bromocriptine decreased responding maintained by either food or cocaine.
These results indicate that bromocriptine can selectively reduce behavior maintained by cocaine , although apparently by a mechanism other than blockade of reinforcing effects.
Psychopharmacology  •  2005  |  View Paper
Pretreatment with bromocriptine selectively reduced the number of cocaine infusions obtained.
Psychopharmacology  •  2005  |  View Paper
Moreover the relative potencies of these and other D2-like dopamine agonists (lisuride, 7-OH-DPAT, quinpirole, apomorphine, bromocriptine ) to modulate cocaine self-administration were highly correlated with their relative potencies for increasing mitogenesis in vitro in cell lines expressing D3 but not D2 receptors.
Neuroreport  •  1997  |  View Paper
Co-administration of a threshold dose of cocaine (1.25 mg/kg) with low doses of bromocriptine (1.25-5 mg/kg) or quinpirole (0.025-0.1 mg/kg) induced higher percentages of cocaine-lever responding as compared with occasions when these D2 agonists were given alone.
The Journal of pharmacology and experimental therapeutics  •  1993  |  View Paper
Bromocriptine , a dopamine agonist, produced dose-dependent decreases in cocaine self-administration at doses of 4.0, 8.0, 16.0, and 32.0 mg/kg.
Given that bromocriptine produced a specific effect on cocaine-maintained responding, the present results suggest that bromocriptine is interacting with the neurochemical substrate mediating the reinforcing effects of cocaine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology  •  1990  |  View Paper
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