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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Bromelains
drug:
Interferon Gamma-1B
Research Papers that Mention the Interaction
“ Bromelain also inhibited PMA-induced IL-2, IFN-gamma , and IL-4 mRNA accumulation, but had no effect on TCR-induced cytokine mRNA production.”
Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells.“ Bromelain also increased IL-2- and IL-12-mediated IFN-gamma production by NK cells.”
“In this study, we show that bromelain , a mixture of cysteine proteases, can enhance IFN-gamma-mediated nitric oxide and TNFalpha production by macrophages.”
“Instead, bromelain either enhanced or acted synergistically with IFN-gamma receptor-mediated signals.”
Bromelain activates murine macrophages and natural killer cells in vitro.
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