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Discover Supplement-Drug Interactions

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Last Updated: 5 years ago

Possible Interaction: Bromelains and Cisplatin

supplement:

Bromelains

Research Papers that Mention the Interaction

“Further, the efficacy of cisplatin and 5-FU are enhanced by adjuvant treatment with bromelain , indicating that the barrier function of MUC1 may be affected.”
“Further, bromelain in combination with either 5-FU or cisplatin , the efficacy of the chemotherapeutic drug is enhanced.”
Cancer investigation  •  2013  |  View Paper
“The addition of bromelain increased the cytotoxicity of cisplatin significantly in both cell lines.”
Anti-cancer drugs  •  2014  |  View Paper
“Conclusion: This study suggests that bromelain treatment could potentiate the antitumor effect of cisplatin on triple-negative breast cancer 4T1 cells through modulating the tumor environmental inflammation.”
Integrative cancer therapies  •  2019  |  View Paper
“Results: Cisplatin (IC10) combined with bromelain (IC40) significantly affected PC3 cell viability, inhibited colony formation, as well increased p53 proapoptotic gene expression compared to cisplatin single treatment.”
Galen medical journal  •  2020  |  View Paper