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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Bromelains
drug:
Aldesleukin
Research Papers that Mention the Interaction
“ Bromelain also inhibited PMA-induced IL-2 , IFN-gamma, and IL-4 mRNA accumulation, but had no effect on TCR-induced cytokine mRNA production.”
Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells.“Additionally, bromelain did not affect TCR and CD28-induced proliferation of highly purified CD4+ T cells, but did inhibit IL-2 production by these cells.”
“However, despite increased T cell proliferation, bromelain concomitantly decreased IL-2 production in splenocyte cultures.”
Bromelain modulates T cell and B cell immune responses in vitro and in vivo.
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