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Last Updated: 6 months ago

Possible Interaction: Brimonidine and Yohimbine



Research Papers that Mention the Interaction

Brimonidine had a protective effect on auditory HCs against gentamicin-induced toxicity that was blocked by yohimbine.
Audiology and Neurotology  •  2017  |  View Paper
Yohimbine competitively blocked the effect of brimonidine on HA release.
Neuropharmacology  •  2009  |  View Paper
The suppressive action of brimonidine and medetomidine was completely blocked by classic alpha2 receptor antagonists, such as yohimbine , rauwolscine, and atipamezole.
Investigative ophthalmology & visual science  •  2007  |  View Paper
The inhibitory effect of brimonidine was prevented by PTX (119% +/- 7%, P < 0.01) and, in a concentration-dependent manner, by yohimbine (10 microM: 134% +/- 9%; P < 0.01), but not by prazosin, nicergoline, or propranolol.
Investigative ophthalmology & visual science  •  2002  |  View Paper
The inhibitory effect of brimonidine on the increase of nitrite production induced by forskolin was significantly (P < 0.01) reversed by yohimbine (136 +/- 7%).
Klinische Monatsblatter fur Augenheilkunde  •  2001  |  View Paper
Yohimbine significantly inhibited the effect of brimonidine on both hyaluronidase activity and cAMP accumulation.
Investigative ophthalmology & visual science  •  2000  |  View Paper
Pretreatment with yohimbine (10(-8)-10(-7) M) or rauwolscine (10(-8)-10(-7) M) caused a parallel shift to the right of the dose-response curve for 5-bromo-6[2-imidazolin-2-ylamino]-quinoxaline.
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper
Acute treatments of rats (not exposed to reserpine) with a … adrenoceptor agonists such as guanfacine 6, B-HT920, xylazine, bromoxidine (1 mg/… such as yohimbine , phentolamine, prazosin (10 or 20 mg/kg) resulted in significant decreases (15%-… increases (21%-99%) in the synthesis of DOPA in both brain regions.
Naunyn-Schmiedeberg's archives of pharmacology  •  1992  |  View Paper
The highly selective α2-AR antagonist yohimbine blocked the effects of brimonidine.
Experimental eye research  •  2019  |  View Paper