Possible Interaction: Brimonidine and Yohimbine

“The highly selective α2-AR antagonist yohimbine blocked the effects of brimonidine.”

“ Brimonidine had a protective effect on auditory HCs against gentamicin-induced toxicity that was blocked by yohimbine.”

“These protective effects of brimonidine can be reversed by yohimbine.”

“ Yohimbine competitively blocked the effect of brimonidine on HA release.”

“The suppressive action of brimonidine and medetomidine was completely blocked by classic alpha2 receptor antagonists, such as yohimbine , rauwolscine, and atipamezole.”

“The inhibitory effect of brimonidine was prevented by PTX (119% +/- 7%, P < 0.01) and, in a concentration-dependent manner, by yohimbine (10 microM: 134% +/- 9%; P < 0.01), but not by prazosin, nicergoline, or propranolol.”

“The inhibitory effect of brimonidine on the increase of nitrite production induced by forskolin was significantly (P < 0.01) reversed by yohimbine (136 +/- 7%).”

“ Yohimbine significantly inhibited the effect of brimonidine on both hyaluronidase activity and cAMP accumulation.”

“Pretreatment with yohimbine (10(-8)-10(-7) M) or rauwolscine (10(-8)-10(-7) M) caused a parallel shift to the right of the dose-response curve for 5-bromo-6[2-imidazolin-2-ylamino]-quinoxaline.”

“Acute treatments of rats (not exposed to reserpine) with a … adrenoceptor agonists such as guanfacine 6, B-HT920, xylazine, bromoxidine (1 mg/… such as yohimbine , phentolamine, prazosin (10 or 20 mg/kg) resulted in significant decreases (15%-… increases (21%-99%) in the synthesis of DOPA in both brain regions.”