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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Trypsin
Research Papers that Mention the Interaction
“Thus, in vitro trypsin can directly liberate both the depressor, bradykinin , in weak alkaline conditions, and the pressor, angiotensin II, at weakly acidic pH, from the appropriate substrates.”
Ability of kallikrein to generate angiotensin II-like pressor substance and a proposed ‘kinin–tensin enzyme system’“The enzyme was present in active and inactive forms (n = 9), since preincubation with trypsin increased kininogenase activity from 54.8 +/- 11.8 to 230 +/- 23 pg bradykinin per milligram protein per minute.”
Adrenal kallikrein.“It was suggested that trypsin enhanced bradykinin effect on the ileum through the release of polypeptides and, probably, other substances from the tissue used for the bioassay.”
“ Trypsin , after an initial selective sensitization to bradykinin , unspecifically damaged the preparation.”
“One mg of the average preparation releases 0.8 to 1.0 μg of bradykinin when incubated with trypsin under the conditions described.”
Studies on the isolation of bradykininogen.
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