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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Bradykinin
supplement:
Quinidine
Research Papers that Mention the Interaction
“… quinidine (2–10 μg/ml) … bradykinin as well as of acetylcholine in proportion to the dose.3.Infusion of postglandin E1 (10 ng/ml) in addition to mepacrine … by inhibiting the release of E-type prostaglandins which sensitize pain receptors and secondarily by an unspecific antagonism (local-anaesthetic action).”
Inhibition of the algesic effect of bradykinin and acetylcholine by mepacrine“Certain blockers of K+ channels, for example charybdotoxin (5-50 …), Ba2+ (5-20 mM), 4-aminopyridine (5-10 mM) and quinidine (0.1-0.5 mM) reversibly … the membrane potential response to bradykinin or to Ins-P3; however, apamin (1 microM) … D-tubocurarine (0.5 mM) had no effect.”
“The K+ channel blockers, Ba2+, quinidine , and 4-aminopyridine, inhibited the response to bradykinin.”
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